Aims: Antibiotic prophylaxis in skull base surgery remains a controversial topic, with limited high-quality evidence to guide optimal agent selection, timing and duration. There is variation in practice across institutions, potentially contributing to antimicrobial resistance and inconsistent infection outcomes. Our aim is to evaluate current trends and variations in antibiotic prescribing practices amongst clinicians performing skull base surgery (including otolaryngologists, neurosurgeons and plastic surgeons) and also to identify factors influencing clinical decision-making. Methods: A cross-sectional, anonymised electronic survey will be distributed via REDCap to clinicians performing skull base surgery, through national otolaryngology and skull base societies. The survey collects data on respondent demographics, surgical case mix, antibiotic selection, timing, duration, and presence of local protocols. Responses will be analysed descriptively, with subgroup comparisons planned by subspecialty, institutional setting and case complexity. A target sample size of approximately 100 respondents is anticipated and survey distribution will begin in December. Anticipated Results: We expect to identify substantial variability in antibiotic prescribing practices for both anterior and lateral skull base procedures, including heterogeneity in duration of prophylaxis and reliance on institutional guidance. The findings are anticipated to highlight areas of uncertainty and inform future consensus development. Conclusion: This national survey aims to characterise current antibiotic prescribing patterns in skull base surgery and to identify opportunities for standardisation and improved antimicrobial stewardship. The results will contribute to the evidence base guiding perioperative infection prevention in complex skull base procedures.