Aims: Congenital CMV screening is relatively new in Australia and there is a lack of data on the how accepted such screening is amongst families. The objective of this project was to explore the experiences and perceptions of parents who participated in the Perth Children's Hospital targeted screening of CMV research project. Methodology: A qualitative study was undertaken of families who were recruited by the Perth Children's Hospital CMV pilot study research team. There was a mixed sample of participants selected, including those who had negative and positive results; this was to enable a variety of perspectives to be obtained. Interviews were conducted either by phone call or videoconference meeting, depending on participant preference. Results: Ten families were interviewed about their study experience. Most described the process as straightforward, though some felt overwhelmed when processing important information. Parents valued learning about CMV and appreciated having the information needed to make informed decisions for their baby. Reported challenges included limited access to testing centres, feelings of guilt surrounding the diagnosis, the need for sensitive communication, and stronger collaboration between different medical teams. Overall, participants expressed positive views about their involvement while also highlighting areas for improvement. Conclusion: This study highlights the sensitive nature of a possible cCMV diagnosis for parents and the process of screening which will inform development of future cCMV screening programs. The findings reveal key areas where communication, support, and system processes can be strengthened.