Background: Reconstruction of large scalp defects is challenging due to limited local tissue mobility, exposed calvarium, and the need for durable soft-tissue coverage. Traditional options such as grafts, rotational flaps, tissue expansion, and free tissue transfer each carry morbidity or technical complexity. The NovoSorb® Biodegradable Temporising Matrix (BTM) provides an alternative by promoting neodermis formation over exposed bone, with or without subsequent grafting. We describe its use in reconstructing a large scalp defect following wide local excision of dermatofibrosarcoma protuberans (DFSP). Case Description: A patient presented with a large scalp DFSP. After multidisciplinary discussion, wide local excision with 2 cm margins and burring of the calvarium was performed, rendering split-thickness skin grafting unsuitable. Reconstructive options included a rotational flap with adjacent skin grafting, free flap, or staged BTM reconstruction. After discussion of risks, recovery, and cosmetic expectations, the patient elected for BTM. Results: BTM integrated successfully, forming a robust neodermis over several weeks, without the need for skin grafting. The postoperative course was complicated by a local wound infection, managed conservatively. Final histopathology confirmed clear margins, and adjuvant radiotherapy was not required. Conclusion: BTM offers a reliable, low-morbidity reconstructive option for scalp defects where conventional techniques may be unsuitable or undesirable. This case demonstrates its effectiveness in achieving durable coverage and satisfactory aesthetic outcomes following large oncologic scalp resection.